On July 21, 1828, the Rev. John Johns, rector of All Saints Episcopal Church in Frederick, tendered his resignation to accept a call to Christ Church, Baltimore. From 1849-1854, while serving as assistant bishop of the Diocese of Virginia, Johns served as the 15th president of the College of William and Mary in Williamsburg. In 1862 he became the fourth Episcopal bishop of Virginia.
On July 21, 1861, Calvin Lamar, of Adamstown, was shot and killed by Samuel Webster, a Union soldier, during a quarrel over the use of a railroad handcar. Webster was arrested by his military superiors at Point of Rocks and later turned over to the Frederick County sheriff.
On July 21, 1863, General George G. Meade's Union troops crossed the Potomac River at Berlin (Brunswick) on a pontoon bridge.
On July 21, 1979, Dr. A. Austin Pearre, prominent local physician and among the founders of the county's Heart Association, died at his home on Upper College Terrace, Frederick. He was born February 1, 1899.